The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells
نویسندگان
چکیده
منابع مشابه
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.
Members of the inhibitor of apoptosis protein (IAP) family play a role in mediating apoptosis. Studies suggest that these proteins may be a viable target in leukemia because they have been found to be variably expressed in acute leukemias and are associated with chemosensitivity, chemoresistance, disease progression, remission, and patient survival. Another promising therapeutic target, FLT3, i...
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ژورنال
عنوان ژورنال: Experimental Hematology & Oncology
سال: 2020
ISSN: 2162-3619
DOI: 10.1186/s40164-019-0157-6